Our research is focused on fundamental and conserved mechanisms that guide the formation and maintenance of synaptic connections within the developing nervous system.  We have used Drosophila genetics, imaging and molecular approaches in the neuromuscular system to define signaling pathways and regulatory mechanisms that neurons use to control their differentiation, morphogenesis and connectivity. Our laboratory works in close collaboration and shared research space with the Artavanis-Tsakonas laboratory (https://artavanis-tsakonas.hms.harvard.edu/research), with whom we have begun to model a variety of neurodegenerative disease models.